It feels like the weight-loss miracle so many have been waiting for. You watch the transformation videos on TikTok, see the celebrities shrinking before your eyes and hear the stories of friends who have effortlessly dropped 30 pounds.
Ozempic (semaglutide) has become the “Kleenex” of diet culture — a catch-all name for a weekly injection that melts fat without the misery of starvation.
But there’s a major catch. These drugs are not a cure. They are a treatment. Like blood pressure medication, they only work as long as you take them.
And there’s one crucial question every potential user should ask before their first dose: What happens when I stop?
The science of the rebound
Clinical trials paint a sobering picture for both major drug types.
For Ozempic and Wegovy (semaglutide) users, research found that one year after stopping the drug, participants regained two-thirds of their lost weight.
For Zepbound (tirzepatide) users, the news is similar. In a study of the drug, all participants took tirzepatide for 36 weeks and lost significant weight. Researchers then switched a randomized portion of the group to a placebo, at which point they regained 14% of their body weight in the following year, effectively erasing the majority of their progress.
It’s a matter of biology. When you lose weight rapidly, your body fights to get it back. It lowers your metabolism and ramps up your hunger hormones.
These drugs work by suppressing those signals. When you remove the drug, the dam breaks. Your body doesn’t just go back to normal. It often swings hard in the other direction to recover lost fat storage.
The return of ‘food noise’
One of the most praised effects of these drugs is the silencing of “food noise” — that constant mental chatter about what to eat next. For many users, this is the first time in their lives they haven’t felt obsessed with food.
When they stop the medication, that noise comes back, often louder than before.
Obesity specialists have noted that patients don’t just feel hungry; they feel an intense, biological drive to eat that can be overwhelming.
Because they haven’t necessarily built the psychological habits or muscle mass to maintain the weight naturally (since the drug did the heavy lifting), they’re left defenseless against these cravings.
The financial reality of a forever prescription
If you’re taking these drugs for weight loss, you need to budget for them like you would a utility bill.
As of early 2026, the pricing has shifted. While retail prices without insurance still hover near $1,000 per month, manufacturers have introduced new cash-pay options (like Zepbound vials or Wegovy intro offers) that can drop the price to the $199 to $399 range for eligible patients.
However, even at $350 a month, you’re looking at roughly $4,200 a year — indefinitely.
If you rely on insurance, remember that coverage is fickle. Medicare is starting to shift its rules regarding weight loss drugs, but there’s no guarantee of coverage. Other insurance coverage varies.
If you change jobs, lose coverage or your insurer changes their formulary, you could be forced to stop cold turkey and face the risk of regaining weight.
The health whiplash
Beyond the number on the scale, stopping these medications can shock your system.
- Blood sugar spikes: If you were using these drugs for Type 2 diabetes or even pre-diabetes, stopping can cause your blood glucose levels to surge. This is dangerous and requires immediate management by a doctor.
- Cardiometabolic regression: The clinical trials also found that improvements in cardiometabolic risk factors (like blood pressure and inflammation markers) reverted to baseline once the weight came back. You lose the heart health protection along with the weight.
Is it worth it?
This doesn’t mean you shouldn’t take them. For people with severe obesity or diabetes, these drugs are lifesavers. But you need to shift your mindset.
Don’t view Zepbound or Ozempic as a jumpstart to get skinny for a wedding or a reunion. Think of it instead as a lifetime management tool for a chronic condition.
If you aren’t willing — or financially able — to take it for the long haul, you might be setting yourself up for an expensive, heartbreaking cycle of yo-yo dieting that leaves you heavier than when you started.